Related Experiment Video
Updated: Apr 18, 2026

Design of a Cyclic Pressure Bioreactor for the Ex Vivo Study of Aortic Heart Valves
Published on: August 23, 2011
Simulation of short-term pressure regulation during the tilt test in a coupled 3D-0D closed-loop model of the
Kevin D Lau1, C Alberto Figueroa
1Department of Biomedical Engineering, King's College London, London, SE1 7EH, UK, kevin.lau@kcl.ac.uk.
Abstract:
Short-term fluctuations in arterial pressures arising from normal physiological function are buffered by a negative feedback system known as the arterial baroreflex. Initiated by altered biomechanical stretch in the vessel wall, the baroreflex coordinates a systemic response that alters heart rate, cardiac contractility and peripheral vessel vasoconstriction. In this work, a coupled 3D-0D formulation for the short-term pressure regulation of the systemic circulation is presented. Including the baroreflex feedback mechanisms, a patient-specific model of the large arteries is subjected to a simulated head up tilt test. Comparative simulations with and without baroreflex control highlight the critical role that the baroreflex has in regulating variations in pressures within the systemic circulation.
Related Concept Videos
Pressure Variation in a Fluid at Rest
When measuring pressure at two different levels within the fluid, the difference in...
Autoregulation of Blood Flow
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
Pressure of Fluids
Fluid Pressure over Curved Plate of Constant Width
Typical Model Studies
Fluid Pressure over Flat Plate of Variable Width
The pressure distribution on the plate can be calculated by determining the force that acts on a differential area strip of the plate. Thus, the magnitude of the force is equal to the...

