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Safety assessment of Tin(IV) oxide as used in cosmetics

Wilbur Johnson1, Wilma F Bergfeld2, Donald V Belsito2

  • 1Cosmetic Ingredient Review Scientific Analyst/Writer, Washington, DC, USA.

International Journal of Toxicology
|January 9, 2015
PubMed

Keywords:
cosmeticssafetytin oxide

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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