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Related Experiment Video

Updated: Apr 18, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Subungual squamous cell carcinoma.

Kai Yuen Wong¹, Daniel L H Ching¹, David Gateley¹

¹Department of Plastic and Reconstructive Surgery, St George's Healthcare NHS Trust, London, UK.

BMJ Case Reports

|January 9, 2015

Summary

Subungual squamous cell carcinoma (SCC), a rare nail cancer, can invade bone. This case highlights the importance of recognizing and managing this aggressive malignancy.

Area of Science:

Oncology
Dermatology
Pathology

Background:

Squamous cell carcinoma (SCC) is a common skin cancer.
Subungual SCC, occurring under the nail, is exceptionally rare.
Early diagnosis is crucial for effective management.

Observation:

A case of subungual SCC with deep invasion into the underlying bone is presented.
The tumor exhibited aggressive characteristics.
Diagnostic challenges in subungual lesions were noted.

Findings:

Histopathological examination confirmed invasive squamous cell carcinoma.
Radiological imaging revealed extensive bone involvement.
Literature review indicates a poor prognosis with advanced disease.

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Implications:

This case underscores the potential for subungual SCC to metastasize to bone.
Timely and accurate diagnosis is essential for improving patient outcomes.
Further research into optimal treatment strategies for invasive subungual SCC is warranted.