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Paroxetine-induced galactorrhea.

Prannay Gulati1, B S Chavan1, Subhash Das1

  • 1Department of Psychiatry, Government Medical College and Hospital, Chandigarh, India.

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|January 9, 2015
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Summary
This summary is machine-generated.

Selective serotonin reuptake inhibitors like paroxetine can cause galactorrhea, a rare side effect. This case highlights paroxetine-induced galactorrhea in a patient with obsessive compulsive disorder, presenting with varying prolactin levels.

Keywords:
Euprolactinemicgalactorrheahyperprolactinemicparoxetine

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Area of Science:

  • Endocrinology
  • Neuroscience
  • Pharmacology

Background:

  • Drug-induced galactorrhea is a known side effect of certain medications, particularly antidopaminergic agents.
  • Selective serotonin reuptake inhibitors (SSRIs) are infrequently associated with galactorrhea, with limited case reports over recent decades.
  • Previous reports show varied prolactin levels (raised or normal) in patients experiencing SSRI-induced galactorrhea.

Purpose of the Study:

  • To report a rare case of paroxetine-induced galactorrhea.
  • To document the occurrence of both hyperprolactinemic and euprolactinemic galactorrhea in the same patient.
  • To highlight the association between paroxetine, galactorrhea, and a pituitary incidentaloma.

Main Methods:

  • A case study approach was utilized.
  • Clinical presentation, medication history, and hormonal levels were assessed.
  • Imaging studies were performed to evaluate for pituitary abnormalities.

Main Results:

  • A 48-year-old female patient with obsessive compulsive disorder developed galactorrhea while on paroxetine.
  • The patient exhibited both hyperprolactinemic and euprolactinemic galactorrhea at different times during treatment.
  • A pituitary incidentaloma was discovered in the patient.

Conclusions:

  • Paroxetine can induce galactorrhea, even in the presence of a pituitary incidentaloma.
  • Galactorrhea associated with paroxetine may present with fluctuating prolactin levels.
  • This case underscores the importance of considering SSRIs in the differential diagnosis of drug-induced galactorrhea.