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Herpes simplex virus type 1 ribonucleotide reductase null mutants induce lesions in guinea pigs
1Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor 48109.
Virology
|December 1, 1989
Abstract:
Two herpes simplex virus type 1 ribonucleotide reductase null mutants, hrR3 and ICP6 delta, produced cutaneous lesions in guinea pigs as severe as those of wild-type strains. The lesions induced by hrR3 resulted from in vivo replication of the mutant virus, suggesting that this virus-encoded enzyme is nonessential for virus replication in guinea pigs.