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Bacterial uropathogens isolates and antibiograms in children under 5 years of age
Mohamed Alkhatim Alsammani1, Mohamed Issa Ahmed1, Nahla Farouk Abdelatif1
1Department of Medical Biochemistry, College of Applied Medical Sciences, Qassim University, Bahri, Sudan.
Insights
Escherichia coli was the most frequent cause of childhood urinary tract infections (UTIs). Ciprofloxacin is recommended for initial empirical treatment of pediatric UTIs pending culture results.
Area of Science:
- Pediatric infectious diseases
- Microbiology
- Antimicrobial resistance
Background:
- Childhood urinary tract infections (UTIs) are common febrile illnesses.
- Antibiotic susceptibility varies among pediatric UTI pathogens.
Purpose of the Study:
- Identify common uropathogens in children under five years old.
- Determine antimicrobial susceptibility patterns of these uropathogens.
Main Methods:
- Evaluated 104 children (2 months - 5 years) with suspected UTIs.
- Collected urine specimens via sterile container or collection bag.
- Microscopic urinalysis, culture, and antimicrobial susceptibility testing were performed.
Main Results:
- E. coli (42.6%) was the most prevalent uropathogen.
- Pseudomonas aeruginosa (29.6%), Klebsiella pneumoniae (18.5%), and Proteus mirabilis were also identified.
- E. coli showed high sensitivity to ciprofloxacin (91.3%).
Conclusions:
- E. coli, P. aeruginosa, K. pneumoniae, and P. mirabilis are key uropathogens in young children.
- Ciprofloxacin is a suitable choice for empirical UTI therapy in this age group.
Background:
Childhood urinary infections are among the most common febrile illnesses occurring during this period with varying susceptibility to antibiotic.
Aim:
The aim of this study was to identify uropathogens responsible to for urinarytract infection (UTIs) in children less than 5 years of age, and determine the antibiograms of the isolates to commonly used antibiotics.
Patients And Methods:
Hundred and four children (2 months - 5 years old) seen at the Gadarif Teaching Hospital from January 2012 and December 2013 were evaluated. A urine specimen was obtained by a plastic bag with an adhesive backing around an opening or by direct voiding into sterile container. Urine was examined microscopically and those with significant pyuria and bacteruria were further cultured and microorganisms were identified and tested for antimicrobial susceptibility.
Results:
Out of 304 children suffering from UTIs; 145(47.7%) had significant pyuria of them; 54(17.8 %) had positive bacterial growth. The frequency of sex and residency were almost the same. E. coli (42.6%) was the most common uropathogen, sensitive to ciprofloxacin (91.3%), followed by Pseudomonas aeruginosa (29.6%) sensitive to Ciprofloxacin (75%)and Norofloxacin (68.8%), Klebsiellapneumoniae (18.5%) sensitive to Ciprofloxacin and Norofloxacin and Nalidixic acid (90%) and Proteus mirabilis sensitive to Ciprofloxacin and Norofloxacin (90%), Amoxicillin / clavulanic acid (Augmentin(80%).
Conclusion:
The most common uropathogens were E. coli, Pseudomonas aeruginosa,Klebsiellapneumoniae, and Proteus mirabilis. Ciprofloxacin is the recommended initial empirical therapy while awaiting the culture and sensitivity results.
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