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Short-term Parameters of Heart Rate Variability During Balanced Anaesthesia with Administration of Two Different
1Clinic of Anaesthesia, Resuscitation and Intensive Care, University Clinical Centre Sarajevo, Bosnia and Herzegovina.
This study found that sevoflurane and isoflurane cause similar changes in heart rate variability and hemodynamics during balanced anesthesia. Both agents are safe for abdominal surgery, with no significant differences observed between them.
Area of Science:
- Anesthesiology
- Cardiovascular Physiology
- Autonomic Nervous System Research
Background:
- Heart rate variability (HRV) reflects autonomic nervous system modulation of heart rate.
- Understanding HRV changes during anesthesia is crucial for patient safety.
Purpose of the Study:
- To compare the effects of sevoflurane and isoflurane on heart rate variability during balanced anesthesia.
- To evaluate hemodynamic stability during anesthesia with these two agents.
Main Methods:
- 64 patients undergoing elective abdominal surgery were randomized into two groups.
- Balanced anesthesia was maintained with either sevoflurane or isoflurane.
- Hemodynamic parameters and ECG (Holter) were monitored; HRV parameters (TP, LF, HF, SD1, SD2) were analyzed.
Main Results:
- Hemodynamic parameters showed perioperative changes without significant inter-group differences.
- Heart rate variability parameters (TP, LF, HF) demonstrated variations during anesthesia with both agents.
- No statistically significant differences in HRV parameters were found between sevoflurane and isoflurane groups.
Conclusions:
- Balanced anesthesia with sevoflurane or isoflurane induces comparable variations in hemodynamic variables and HRV.
- Neither agent showed a statistically significant advantage over the other in this study.
- Both agents appear to be suitable for balanced anesthesia in abdominal surgery.
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