Related Experiment Video
Updated: Apr 18, 2026
Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
Improvement of ejection fraction after coronary artery bypass grafting surgery in patients with impaired left
Ilirijana Haxhibeqiri-Karabdic1, Aida Hasanovic2, Emir Kabil3
1Heart Center, Clinical Center of Sarajevo University, Sarajevo, Bosnia and Herzegovina.
Insights
Coronary artery bypass grafting is safe for patients with severe left ventricular dysfunction. The procedure improves ejection fraction and quality of life in this high-risk group.
Area of Science:
- Cardiovascular Surgery
- Cardiac Surgery
- Heart Failure Management
Background:
- Severe left ventricular (LV) dysfunction with low ejection fraction (EF <35%) presents challenges for myocardial revascularization.
- Coronary artery bypass grafting (CABG) in these patients is controversial due to concerns about morbidity, mortality, and quality of life.
Purpose of the Study:
- To evaluate the safety and efficacy of CABG in patients with severe LV dysfunction and low EF.
- To assess the impact of CABG on LV function and patient quality of life.
Main Methods:
- A retrospective study of 40 patients with severe coronary artery disease and EF <35% who underwent CABG over three years.
- Preoperative assessment included clinical evaluation, echocardiography (EHO), MRI, and cardiac catheterization.
- Internal mammary artery was utilized in all cases.
Main Results:
- The average patient age was 59.8 years, with 81.3% males.
- The majority of patients had multi-vessel disease (42.5% three-vessel, 40% two-vessel).
- Preoperative EF (18%-27%) improved significantly to 31.08% within 30 days post-CABG.
Conclusions:
- CABG can be safely performed in patients with severe LV dysfunction.
- The procedure leads to significant improvements in left ventricular ejection fraction.
- Enhanced quality of life is observed post-revascularization in this patient cohort.
Objectives:
The present study evaluates our experience with aorto-coronary bypass grafting in patients with severe dysfunction of left ventricle (LV) and low ejection fraction-EF(<35%). Revascularization of myocardium in this settings remains contraversial because of concerns over morbidity, mortality and quality of life.
Material And Methodes:
Forty patients with severe coronary artery disease and dysfunction of LV (low ejection fraction <35%) underwent coronary artery bypass grafting in period of 3 years. Preoperative diagnostic of 40 patients was consisted of anamnesis, clinical exam, non-invasive methods EHO, MR and invasive diagnostic methods-cateterization. The major indication for surgery was severe anginal pain, heart failure symptoms and low ejection fraction. Internal mammary artery was used in all operated patients.
Results:
Average age of patients who have been operated was 59,8. In the present study, 81,3% were male and 18,8% female. We found one-vessel disease present in 2,5% (1/40) of patients, two -vessel disease in 40% (16/40), three-vessel disease in 42,5% (17/40) and four -vessel disease in 15% (6/40) of patients. One bypass grafting we implanted in 2,5% patients, two bypasses in 42,5%, three bypasses in 45 5%, and four bypasses in 10% of patients. Left ventricular ejection fraction assessed preoperativly was 18%-27% and postoperatively was improved to 31, 08% in period of 30 days.
Conclusion:
In patients with left ventricular dysfunction, coronary artery bypass grafting can be performed safely with improvement in quality of life and in left ventricular ejection fraction.
Related Concept Videos
01:29Cardiomyopathy V: Interprofessional Care
01:30Cardiomyopathy II: Dilated Cardiomyopathy