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Articles linked to this work by shared authors, journal, and citation graph.

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Sensing Muscle Deformation for Upper-Limb Prosthetic Control: a Narrative Review.

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Related Experiment Video

Updated: Apr 18, 2026

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
07:30

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

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Electrically stimulated signals from a long-term Regenerative Peripheral Nerve Interface.

Nicholas B Langhals, Shoshana L Woo, Jana D Moon

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |January 9, 2015
    PubMed
    Summary

    Regenerative Peripheral Nerve Interfaces (RPNIs) provide reliable signals for prosthetic limbs even after 14 months. This muscle graft interface shows long-term viability and consistent signal acquisition for advanced neuroprosthetics.

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    Area of Science:

    • Biomedical Engineering
    • Neuroscience
    • Prosthetics

    Background:

    • Current upper extremity prostheses offer limited functional recovery.
    • Optimal prosthetic interfaces for high-fidelity control are lacking.
    • Regenerative Peripheral Nerve Interfaces (RPNIs) offer a novel solution.

    Purpose of the Study:

    • To evaluate the signal quality and reliability of RPNIs after long-term implantation.
    • To assess the viability and health of RPNIs after an extended maturation period.

    Main Methods:

    • RPNIs were implanted and allowed to mature for 14 months.
    • Electromyographic signals were recorded via surface electrodes on the muscle.
    • Nerve stimulation was used to evoke muscle action potentials.
    • Histological analysis was performed to assess tissue health.

    Main Results:

    • RPNIs remained viable and healthy after 14 months.
    • Consistent electromyographic signals exceeding 4 mV were acquired.
    • Evoked compound muscle action potentials confirmed nerve regeneration and muscle function.
    • Histological analysis showed no signs of denervation, scarring, or necrosis.

    Conclusions:

    • RPNIs demonstrate long-term viability and reliability for prosthetic control.
    • Consistent and high-quality signals can be acquired from RPNIs after more than one year.
    • RPNIs represent a promising interface for advanced neuroprosthetic limbs.