Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Signal transduction pathways in mitogenesis.

E Rozengurt

    British Medical Bulletin
    |April 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Quiescent cells can be stimulated to divide by various factors, including bombesin-like peptides. These peptides activate multiple signaling pathways that cooperate for cell proliferation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Protein Kinase D1 (PKD1) Signaling Induces Growth-Promoting Effects in Murine Enteroids.

    Cellular and molecular gastroenterology and hepatology·2020
    Same author

    Metformin Restrains Pancreatic Duodenal Homeobox-1 (PDX-1) Function by Inhibiting ERK Signaling in Pancreatic Ductal Adenocarcinoma.

    Current molecular medicine·2015
    Same author

    Everolimus inhibits anti-HLA I antibody-mediated endothelial cell signaling, migration and proliferation more potently than sirolimus.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014
    Same author

    Blockade of p-selectin is sufficient to reduce MHC I antibody-elicited monocyte recruitment in vitro and in vivo.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013
    Same author

    Stimulation of the neurokinin 3 receptor activates protein kinase C epsilon and protein kinase D in enteric neurons.

    American journal of physiology. Gastrointestinal and liver physiology·2008
    Same author

    CCK(B)/gastrin receptor mediates synergistic stimulation of DNA synthesis and cyclin D1, D3, and E expression in Swiss 3T3 cells.

    Journal of cellular physiology·2001

    Area of Science:

    • Cell biology
    • Molecular signaling

    Background:

    • Quiescent cells (Go phase) can be induced to divide by external stimuli.
    • Polypeptide growth factors, pharmacological agents, and neuropeptides trigger cell division with synergistic effects.

    Purpose of the Study:

    • To elucidate the signaling pathways involved in mitogenesis using bombesin-like peptides as model mitogens.
    • To compare early molecular events induced by bombesin-like peptides with those of other growth factors.

    Main Methods:

    • Stimulation of quiescent cells with bombesin-like peptides.
    • Measurement of ionic fluxes, inositol polyphosphate formation, protein kinase activation, and proto-oncogene expression.
    • Comparative analysis of molecular events induced by different growth factors.

    Related Experiment Videos

    Main Results:

    • Bombesin-like peptides induce rapid increases in ionic fluxes, inositol polyphosphate formation, protein kinase activation, and proto-oncogene expression.
    • Comparison reveals distinct early molecular events compared to other growth factors, suggesting multiple signal-transduction pathways.
    • Evidence for cooperation between separate signal-transduction pathways in response to single or multiple factors.

    Conclusions:

    • Cell proliferation is stimulated by the activation of separate, cooperating signal-transduction pathways.
    • Bombesin-like peptides are valuable tools for dissecting the complex molecular mechanisms of mitogenesis.
    • Understanding these pathways is crucial for comprehending cell cycle regulation and growth factor action.