Related Experiment Video
Updated: Apr 22, 2026

Glycan Node Analysis: A Bottom-up Approach to Glycomics
Published on: May 22, 2016
[The quantity and distribution of specific glycoproteins in gastric carcinoma]
Abstract:
42 tissue samples of gastric carcinoma were stained by HE, PAS and AB, and treated by Immuno-histochemistry ABC with 7 kinds of Lectin to study the meaning of the changes of glycoprotein in their different types and different sites of the gastric mucosa. The binding indexes of Dolichos biflorus agglutinin (DBA) (6.81) and Soybean agglutinin (SBA) (7.02) were strong (P less than 0.01) in mucus carcinoma. In undifferentiated glandular carcinoma, Wheat germ agglutinin (WGA) was high (6.98, P less than 0.05). WGA staining in the tumor of invaded nerves or vessels was strong. The reactions of Ricinus communis agglutinin (RCA) and WGA in most tumors were stronger than those of the other Lectins. Some positive areas of Lectin binding were negatively presented after treating with PAS and AB methods. The results indicated that Lectin binding was more sensitive than classical histochemical methods. The changes of DBA and SBA showed increased N-acetyl-D-galactosamine in mucus carcinoma. The changes of WGA suggested that the increased sialic acid reaction was related to the differentiation, invasion and metastasis of tumor.
More Related Videos
10:28Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
10:59Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
Published on: February 7, 2025
Related Concept Videos
Protein Glycosylation
Glycosylation occurs in...
Proteoglycans
Matrix Proteoglycans and Glycoproteins
Hormones Secreted by the Stomach
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
Gastritis II: Pathophysiology