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Microinjectrode System for Combined Drug Infusion and Electrophysiology

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Published on: November 13, 2019

Injection-depth-locking axial motion guided handheld micro-injector using CP-SSOCT.

Gyeong Woo Cheon, Yong Huang, Hye Rin Kwag

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|January 9, 2015

Summary

This study introduces a handheld micro-injector with common-path swept source optical coherence tomography (CP-SSOCT) for precise depth control. The system achieved an average deviation error of 4.12 um in guiding needles for accurate micro-injections.

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Area of Science:

Biomedical Engineering
Medical Devices
Optical Imaging

Background:

Accurate control of injection depth is critical for targeted drug delivery and minimally invasive procedures.
Existing micro-injection systems often lack real-time feedback and precise depth-locking capabilities.
Optical coherence tomography (OCT) offers high-resolution cross-sectional imaging for subsurface visualization.

Purpose of the Study:

To develop and evaluate a handheld micro-injector system with integrated common-path swept source optical coherence tomography (CP-SSOCT) for highly accurate injection-depth-locking.
To enable real-time, precise, and intuitive freehand control of micro-injections.
To demonstrate the system's capability in guiding needles to a target depth with minimal deviation.

Main Methods:

A handheld micro-injector system was designed incorporating CP-SSOCT as a distal sensor.
Graphics processing unit (GPU) was utilized for high-throughput processing of oversampled OCT signals.
A customized motion monitoring control algorithm was developed for real-time feedback and control.
Performance was evaluated through 60 insertion tests and fluorescein dye injection trials.

Main Results:

The system demonstrated highly accurate injection-depth-locking capabilities.
Real-time, precise freehand control was achieved using GPU processing and the control algorithm.
Evaluation tests showed an average deviation error of 4.12 um in guiding the injection needle to the desired depth.
Successful injection of 50 nl of fluorescein dye was performed with high depth accuracy.

Conclusions:

The developed handheld micro-injector system with CP-SSOCT provides accurate and reliable depth control for micro-injections.
The integration of advanced processing and control algorithms enables precise freehand operation.
This technology holds potential for improving targeted therapies and minimally invasive interventions.