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Updated: Apr 18, 2026

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
Published on: May 22, 2018
Simultaneous stimulation and recording of cardiac depolarization enabled by high-frequency stimulation
Abstract:
High-frequency stimulation techniques have been recently proposed for the pacing and control of excitability of cardiac tissues. This paper introduces a system designed specifically for such stimulation, and demonstrates the unique ability to record depolarization events on the same electrode used for stimulation, during the stimulus. Experimental results with HL-1 cardiomyocytes are presented, highlighting key concepts enabled by this system, such as direct strength-duration relationship measurement and beat-to-beat stimulation threshold monitoring following pacing onset or pharmacological modulation.
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