Related Experiment Video
Updated: Apr 18, 2026
09:33
Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
Published on: December 26, 2016
8.6K
Periodontitis: a potential risk factor for Alzheimer's disease
T L Cerajewska1, M Davies1, N X West1
1Clinical Trials Group, School of Oral and Dental Science, Lower Maudlin Street, University of Bristol, Bristol, BS1 2LY.
British Dental Journal
|January 10, 2015
Summary
Periodontitis is linked to sporadic late-onset Alzheimer's disease (SLOAD). Periodontal pathogens may contribute to brain inflammation, strengthening this association.
Area of Science:
- Oral health and neurology
- Neuroinflammation research
- Infectious disease links to systemic conditions
Background:
- Periodontitis is a known risk factor for various systemic diseases.
- Emerging evidence suggests a connection between periodontitis and sporadic late-onset Alzheimer's disease (SLOAD).
- Recent studies highlight epidemiologic, microbiologic, and inflammatory links.
Purpose of the Study:
- To review and present current evidence on the association between periodontitis and SLOAD.
- To explore the potential role of periodontal pathogens in neuroinflammation.
- To consolidate findings strengthening the link between oral health and Alzheimer's disease.
Main Methods:
- Review of recent epidemiologic data.
- Analysis of microbiologic findings in periodontitis patients.
- Examination of inflammatory markers associated with periodontitis and SLOAD.
- Synthesis of existing literature on the topic.
Main Results:
- Growing body of evidence supports an association between periodontitis and SLOAD.
- Periodontal pathogens are implicated as potential contributors to neural inflammation.
- Inflammatory pathways may link oral infections to Alzheimer's pathology.
Conclusions:
- The association between periodontitis and SLOAD is increasingly recognized.
- Periodontal disease may represent a modifiable risk factor for Alzheimer's disease.
- Further research is warranted to elucidate the causal mechanisms and therapeutic implications.
Related Concept Videos
01:29Alzheimer Disease l: Introduction
2
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
2
01:26Alzheimer's Disease: Overview
2.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
2.0K
01:23Alzheimer Disease ll: Pathophysiology
1
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
1
01:22Alzheimer's Disease: Treatment
1.3K
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
1.3K
01:22Dementia l: Introduction
1
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
1
01:27The Oral Microbiota
59
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
59