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Updated: Apr 18, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
Memory impairment and alterations in prefrontal cortex gamma band activity following methamphetamine sensitization
Sarine S Janetsian1, David N Linsenbardt, Christopher C Lapish
1Department of Psychology, Indiana University-Purdue University Indianapolis, 402 N. Blackford, LD 124, Indianapolis, IN, 46202, USA, sjanetsi@iupui.edu.
Rationale:
Repeated methamphetamine (MA) use leads to increases in the incentive motivational properties of the drug as well as cognitive impairments. These behavioral alterations persist for some time following abstinence, and neuroadaptations in the structure and function of the prefrontal cortex (PFC) are particularly important for their expression. However, there is a weak understanding of the changes in neural firing and oscillatory activity in the PFC evoked by repeated drug use, thus complicating the development of novel treatment strategies for addiction.
Objectives:
The purpose of the current study was to assess changes in cognitive and brain function following MA sensitization.
Methods:
Sensitization was induced in rats, then temporal and recognition memory were assessed after 1 or 30 days of abstinence. Electrophysiological recordings from the medial PFC were also acquired from rats whereupon simultaneous measures of oscillatory and spiking activity were examined.
Results:
Impaired temporal memory was observed after 1 and 30 days of abstinence. However, recognition memory was only impaired after 1 day of abstinence. An injection of MA profoundly decreased neuronal firing rate and the anesthesia-induced slow oscillation (SO) in both sensitized (SENS) and control (CTRL) rats. Strong correlations were observed between the SO and gamma band power, which was altered in SENS animals. A decrease in the number of neurons phase-locked to the gamma oscillation was also observed in SENS animals.
Conclusions:
The changes observed in PFC function may play an integral role in the expression of the altered behavioral phenotype evoked by MA sensitization.
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