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Anti-TNFs in axial spondyloarthritis
Roland Kocijan1, Christian Muschitz, Jürgen Rech
1St. Vincent Hospital-Medical Department II, Academic Teaching Hospital, The VINFORCE Study Group, Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria, roland.kocijan@bhs.at.
Abstract:
Since there is no evidence regarding the efficacy of conventional synthetic disease modifying anti-rheumatic drugs in the improvement of axial spondyloarthritis (SpA), anti-tumor necrosis factors (anti-TNFs) are recommended if nonsteroidal anti-inflammatory drugs fail, or in case of high disease activity. Anti-TNFs show encouraging data regarding pain reduction, improved mobility and quality of life in both ankylosing spondylitis and non-radiographic axial spondyloarthritis. However, withdrawal of anti-TNF therapy leads to relapse of disease activity in SpA. Moreover, osteoproliferation does not seem to be influenced by anti-TNFs.
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