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Updated: Apr 18, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
Treatment of Clostridium difficile infections
Melinda M Soriano1, Stuart Johnson2
1Department of Pharmacy, Presence Resurrection Medical Center, 7435 West Talcott Avenue, Chicago, IL 60631, USA.
Abstract:
Vancomycin and metronidazole were historically considered equivalent therapies for the management of Clostridium difficile infections (CDI); however, recent data confirm more favorable outcomes with vancomycin. Fidaxomicin is a narrow spectrum antibiotic that has an advantage in reducing recurrence rates compared with vancomycin, possibly owing to its sparing effect on normal colonic microbiota. Data are limited for guiding management of CDI recurrences, particularly multiple recurrences. Several empiric approaches to manage these cases are reviewed.
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