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Complement-independent neutralising monoclonal antibody with differential reactivity for strains of human

C Baboonian1, K Blake, J C Booth

  • 1Department of Medical Microbiology, St. George's Hospital Medical School, University of London, England.

Journal of Medical Virology
|October 1, 1989
PubMed

A mouse monoclonal antibody with complement-independent neutralising activity against cytomegalovirus (CMV) and reactive with the 86 kilodalton (kDa) viral glycoprotein H is described. Neutralisation tests against a range of different strains of CMV showed significant crossreactivity, but clear differences were evident between the two prototype viruses AD169 and Davis, and particularly between AD169 and several low-passage recent clinical isolates; CMV present in urine was neutralised weakly if at all.

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