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Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry
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Exploring the conformational variability in the heme b propionic acid side chains through the effect of a biological

Alberto De Petris1, Barbara Chiavarino, Maria Elisa Crestoni

  • 1Dipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma La Sapienza , P.le A. Moro 5, I-00185, Roma, Italy.

The Journal of Physical Chemistry. B
|January 10, 2015
PubMed

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In an organic molecule, free rotation about the carbon-carbon single bond results in energetically different conformers of the molecule. Due to this rotation, called the internal rotation, ethane has two major conformations — staggered and eclipsed.
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The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal...
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