[Current treatment of malignant ovarian germ cell tumors]

Thirty-two patients were treated for ovarian germ cell malignomas, first, along with surgery, with a combined chemotherapy (vincristine, actinomycin D, cyclophosphamide) up to 18 treatments and later up to 6 treatments, except in immature teratomas and advanced cases. At present, in the third stage of the disease a new protocol is applied: cis-platinum, vinblastine, and bleomycin. Four patients with dysgerminoma were surgically treated (two were subsequently irradiated). Only two patients died--one with an endodermal sinus tumour and one with a mixed malignoma, both in the third stage of the disease. The remaining patients are alive and feel well. Except for three, all of them have been followed up for more than five years.