[Human papillomavirus types and cervical neoplasia]

The pathological cells of the cervix uteri were examined for the presence of some types of human papilloma viruses (HPV) by DNA-hybridization and by the Southern blot method. Different degrees of neoplasia were found in the majority of these pathological changes of the uterus. The control group of patients included in the study had normal clinical, cytological and colposcopical results. Two parameters were identical both in the examined and the control patients. Types 6/11 were found in neither of the groups examined. The control patients had types 16/18 HPV in 8.3% of cases, while the frequency of these types was much higher in the examined group; it depended on the phase of the disease. These types were not detected in pathological lesions of CIN I; 40% of patients with CIN II had them, and 7.3% of patients with CIN III were positive to types 16/18 HPV. The majority (75%) of the examined samples of invasive neoplastic cervical lesions were positive to the presence of HPV 16/18.