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Radiopaque, iodine functionalized, phenylalanine-based poly(ester urea)s.

Shan Li1, Jiayi Yu, Mary Beth Wade

  • 1Departments of †Polymer Science and ‡Biomedical Engineering, The University of Akron , Akron, Ohio 44325, United States.

Biomacromolecules
|January 10, 2015
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Summary

Researchers developed novel iodine-containing poly(ester urea)s (PEUs) from phenylalanine. These materials exhibit tunable radiopacity and mechanical properties, showing promise for medical devices requiring imaging verification.

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Materials Engineering

Background:

  • Medical device placement often requires imaging for verification.
  • Developing radiopaque materials can enhance procedural safety and efficacy.
  • Poly(ester urea)s (PEUs) offer tunable properties for biomedical applications.

Purpose of the Study:

  • To synthesize and characterize novel iodine-functionalized phenylalanine-based poly(ester urea)s (PEUs).
  • To investigate the effect of varying iodine content on the thermal, mechanical, and radiopacity properties of PEUs.
  • To assess the biocompatibility of these novel PEUs for potential biomedical applications.

Main Methods:

  • Synthesis of two monomers: bis-4-I-L-phenylalanine-1,6-hexanediol-diester (1-IPHE-6) and bis-L-phenylalanine-1,6-hexanediol-diester (1-PHE-6).
  • Copolymerization of 1-IPHE-6 and 1-PHE-6 monomers in varying feed ratios.
  • Characterization using thermal analysis, mechanical testing (compression tests), and microcomputed tomography (μ-CT).
  • In vitro biocompatibility assessment using MC3T3 cell viability and spreading studies.

Main Results:

  • Copolymer composition and properties were modulated by varying the feed ratio of iodine-containing and non-iodine-containing monomers.
  • Increased iodine content led to enhanced X-ray contrast, as demonstrated by μ-CT.
  • The poly(1-IPHE-6)0.24-co-poly(1-PHE-6)0.76 copolymer exhibited the highest compression modulus in both dry and wet conditions.
  • PEUs demonstrated no toxicity to MC3T3 cells, indicating good biocompatibility.

Conclusions:

  • Iodine-functionalized phenylalanine-based PEUs can be synthesized with tunable radiopacity and mechanical strength.
  • These materials show potential for use in medical devices where inherent X-ray contrast is advantageous for imaging.
  • The developed PEUs are biocompatible and suitable for further investigation in biomedical applications.