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Flatfish metamorphosis: a hypothalamic independent process?

Marco A Campinho1, Nadia Silva1, Javier Roman-Padilla2

  • 1Comparative and Molecular Endocrinology Group, Marine Science Centre (CCMAR), Universidade do Algarve, Faro 8005-139, Portugal.

Molecular and Cellular Endocrinology
|January 11, 2015
PubMed
Summary
This summary is machine-generated.

Thyroid hormones regulate flatfish metamorphosis. This study found no evidence for hypothalamic thyrotropin-releasing hormone (TRH) or corticotropin-releasing hormone (CRH) involvement in sole metamorphosis, questioning their role in regulating thyrotrophs.

Keywords:
AxisFlatfishHypothalamusMetamorphosisPituitaryThyroid

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Area of Science:

  • Developmental Biology
  • Endocrinology
  • Comparative Physiology

Background:

  • Thyroid hormones are essential for anuran and flatfish metamorphosis.
  • The hypothalamus-pituitary-thyroid (HPT) axis centrally regulates thyroid function in vertebrates.
  • In teleosts, hypothalamic regulation of the HPT axis is proposed to be inhibitory, but the specific factors remain unclear.

Purpose of the Study:

  • To investigate the central regulation of flatfish metamorphosis in sole.
  • To explore the role of the hypothalamus-pituitary-thyroid (HPT) axis in regulating thyroid hormone production during sole metamorphosis.

Main Methods:

  • Whole mount in situ hybridization (WISH) was employed to analyze gene expression patterns.
  • Quantitative PCR (qPCR) was used to measure gene expression levels in sole.

Main Results:

  • The study revealed integrated activity between pituitary thyrotrophs and thyroid follicles during sole metamorphosis.
  • No evidence supported a role for hypothalamic thyrotropin-releasing hormone (TRH) or corticotropin-releasing hormone (CRH) in controlling thyroid hormone production.
  • Hypothalamic TRH and CRH expression levels did not change during sole metamorphosis.

Conclusions:

  • The findings challenge the established roles of TRH and CRH in the hypothalamic control of thyrotrophs during teleost metamorphosis.
  • The study suggests that the hypothalamus may not directly regulate thyrotrophs via TRH or CRH in sole metamorphosis, indicating alternative regulatory mechanisms.