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Updated: Apr 18, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Bioactive fused heterocycles: Nucleoside analogs with an additional ring
Zofia Jahnz-Wechmann1, Grzegorz Framski1, Piotr Januszczyk1
1Institute of Bioorganic Chemistry, Polish Academy of Science, Z. Noskowskiego 12/14, PL-61704, Poland.
Abstract:
The following mini-review summarizes the basic literature data regarding synthesis, biological activity, structure-activity relationship, and discussion of the mechanisms of action of two major classes of nucleoside analogs with fused heterocyclic rings: (i) the ethenonucleosides and their related derivatives of the 5,9-dihydro-3-glycosyl-6-alkyl-9-oxo-5H-imidazo[1,2-a]purine type; (ii) the bicyclic nucleosides of 6-alkyl-2,3-dihydrofurano[2,3-d]-pyrimidin-2(3H)-one and 6-alkyl-2,3-dihydropyrrolo[2,3-d]-pyrimidin-2(3H,7H)-one.
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