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Sulfated glycans in inflammation.

Vitor H Pomin1

  • 1Program of Glycobiology, Institute of Medical Biochemistry Leopoldo de Meis, and University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-913, Brazil.

European Journal of Medicinal Chemistry
|January 11, 2015
PubMed
Summary

Sulfated glycans are complex sugars that play a key role in inflammation. They help control how immune cells move and behave during inflammatory responses. These molecules can be found in mammals and marine organisms. The review explores how different types of sulfated glycans, such as heparins and fucoidans, reduce inflammation. They work by regulating chemokines, which guide immune cells. They also help maintain the structure of tissues. This understanding can help develop new drugs to treat inflammatory diseases. The study synthesizes current knowledge to support future research and therapeutic applications.

Keywords:
Carbohydrate-based drug developmentFucoidanFucosylated chondroitin sulfateGlycosaminoglycansHeparinInflammationglycosaminoglycansinflammatory disorderschemokine regulationcarbohydrate-based drugs

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