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[An in vitro study of dentin hypersensitivity using calcium phosphate cement]
Shika Zairyo, Kikai = Journal of the Japanese Society for Dental Materials and Devices
|March 1, 1989
Summary
Calcium phosphate remineralizing slurry (CPRS) effectively desensitizes hypersensitive dentin by forming hydroxyapatite (HAp) crystals. CPRS significantly obturates dentinal tubules, blocking open tubules and reducing sensitivity.
Area of Science:
- Biomaterials Science
- Dental Materials Science
- Crystallography
Background:
- Hypersensitive dentin results from exposed dentinal tubules.
- Calcium phosphate remineralizing slurry (CPRS) forms hydroxyapatite (HAp) in situ.
- CPRS is a mixture of tetracalcium phosphate (TTCP) and dicalcium phosphate dihydrate (DCPD).
Purpose of the Study:
- To investigate the efficacy of topical CPRS in obturating dentinal tubules.
- To evaluate the effects of CPRS on etched dentin surfaces for desensitization.
- To compare different CPRS application methods and durations.
Main Methods:
- Etched dentin surfaces were treated with CPRS.
- Three groups were used: saliva-like solution (control), CPRS treatment (10-min and 1-hr), and viscous CPRS with carboxymethyl cellulose (CMC) gel (8-hr).
- Scanning Electron Microscopy (SEM) was used to observe crystal formation and tubule penetration.
Main Results:
- Control specimens showed octacalcium phosphate (OCP) crystals with minimal tubule penetration.
- CPRS treatments formed dense layers of crystals (10-15 microns thick) with significant penetration into dentinal tubules.
- Viscous CPRS with CMC gel created a highly impervious layer of crystals.
Conclusions:
- CPRS effectively obturates exposed dentinal tubules, indicating potential for dentin desensitization.
- The duration and formulation of CPRS influence the extent of tubule occlusion.
- CPRS demonstrates promise as a biomaterial for managing dentin hypersensitivity.