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[Fecal microbiota transplantation: review].

F Barbut1, A Collignon2, M-J Butel3

  • 1Laboratoire Clostridium difficile associé au CNR des anaérobies et du botulisme, unité du lutte contre les infections nosocomiales (UHLIN), hôpital Saint-Antoine, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France; Groupe de recherche clinique n(o) 2 EPIDIFF, université Pierre-et-Marie-Curie, 75012 Paris, France.

Annales Pharmaceutiques Francaises
|January 12, 2015
PubMed
Summary

Fecal microbiota transplantation (FMT) effectively treats recurrent Clostridium difficile infection by restoring gut microbiota. For other conditions, FMT remains experimental and requires further clinical evidence.

Keywords:
Clostridium difficileDysbiose intestinaleFecal transplantationGut dysbiosisGut microbiotaMicrobiote intestinalTransplantation fécale

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Area of Science:

  • Microbiome Research
  • Gastroenterology
  • Infectious Diseases

Background:

  • Growing medical interest in the gut microbiota's role in disease development.
  • Disturbed colonic microbiota is implicated in various pathologies.
  • Fecal microbiota transplantation (FMT) emerges as a potential therapeutic strategy.

Purpose of the Study:

  • To review the current status and applications of FMT.
  • To highlight FMT's established role in treating recurrent Clostridium difficile infection (RCDI).
  • To discuss the experimental nature of FMT for other diseases.

Main Methods:

  • Review of existing medical literature and clinical evidence on FMT.
  • Analysis of FMT's efficacy in RCDI and other conditions.
  • Assessment of the current procedural standardization and therapeutic mechanisms.

Main Results:

  • FMT is an established treatment for RCDI, likely due to microbiota normalization.
  • Lack of standardization persists in current FMT procedures.
  • FMT is considered experimental for diseases beyond RCDI.

Conclusions:

  • FMT shows therapeutic potential, particularly for RCDI, by restoring colonic microbiota.
  • Further clinical investigation and standardization are crucial for broader FMT application.
  • Expectations for FMT in non-RCDI conditions should be managed pending future evidence.