Related Experiment Video
Updated: Apr 18, 2026
05:41
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Published on: April 6, 2022
3.6K
[Fecal microbiota transplantation: review]
F Barbut1, A Collignon2, M-J Butel3
1Laboratoire Clostridium difficile associé au CNR des anaérobies et du botulisme, unité du lutte contre les infections nosocomiales (UHLIN), hôpital Saint-Antoine, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France; Groupe de recherche clinique n(o) 2 EPIDIFF, université Pierre-et-Marie-Curie, 75012 Paris, France.
Annales Pharmaceutiques Francaises
|January 12, 2015
Summary
Fecal microbiota transplantation (FMT) effectively treats recurrent Clostridium difficile infection by restoring gut microbiota. For other conditions, FMT remains experimental and requires further clinical evidence.
Area of Science:
- Microbiome Research
- Gastroenterology
- Infectious Diseases
Background:
- Growing medical interest in the gut microbiota's role in disease development.
- Disturbed colonic microbiota is implicated in various pathologies.
- Fecal microbiota transplantation (FMT) emerges as a potential therapeutic strategy.
Purpose of the Study:
- To review the current status and applications of FMT.
- To highlight FMT's established role in treating recurrent Clostridium difficile infection (RCDI).
- To discuss the experimental nature of FMT for other diseases.
Main Methods:
- Review of existing medical literature and clinical evidence on FMT.
- Analysis of FMT's efficacy in RCDI and other conditions.
- Assessment of the current procedural standardization and therapeutic mechanisms.
Main Results:
- FMT is an established treatment for RCDI, likely due to microbiota normalization.
- Lack of standardization persists in current FMT procedures.
- FMT is considered experimental for diseases beyond RCDI.
Conclusions:
- FMT shows therapeutic potential, particularly for RCDI, by restoring colonic microbiota.
- Further clinical investigation and standardization are crucial for broader FMT application.
- Expectations for FMT in non-RCDI conditions should be managed pending future evidence.
Related Concept Videos
01:50What is Monogastric Digestion?
79.7K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
79.7K
01:30Development of Human Microbiota
50
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
50
01:27Microbiota of the Large Intestine
80
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
80
01:22Introduction to the Human Microbiota
128
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
128
01:18Functions of the Gut Microbiota
106
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
106
01:29Bacterial Flora of the Large Intestine
2.0K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
2.0K