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Updated: Apr 18, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.3K

[Long noncoding RNAs in prostate cancer]

Zhang-qun Ye1, Tao Wang, Wen Song

  • 1Department of Urology, Tongji Hospital, Huazhong University of Science and Technology, Hubei, China. zhangqun_ye@163.com

Zhonghua Nan Ke Xue = National Journal of Andrology
|January 13, 2015
PubMed

Insights

Long non-coding RNAs (lncRNAs) regulate gene expression and are implicated in cancer. This review explores lncRNA roles in prostate cancer, offering insights for clinical applications.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are RNA molecules >200 nucleotides without protein-coding potential.
  • lncRNAs regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels.
  • Aberrant lncRNA expression is linked to tumor development, invasion, metastasis, and prognosis.

Purpose of the Study:

  • To review recent advancements in understanding lncRNA functions in prostate cancer.
  • To identify potential new avenues for clinical prevention, diagnosis, and treatment of prostate cancer.

Main Methods:

  • Literature review of studies on lncRNAs and prostate cancer.
  • Analysis of lncRNA involvement in prostate cancer's multi-step development process.

Main Results:

  • lncRNAs significantly impact cellular processes like growth, proliferation, differentiation, metabolism, and apoptosis.
  • Abnormal lncRNA expression is a key factor in prostate cancer progression.
  • lncRNAs offer potential as biomarkers and therapeutic targets in prostate cancer.

Conclusions:

  • lncRNAs play a critical role in the pathogenesis of prostate cancer.
  • Further research into lncRNAs may yield novel strategies for prostate cancer management.

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