Related Experiment Video
Updated: Apr 18, 2026

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
Published on: April 12, 2024
[Synthesis and antifatigue activities of new benzamide derivatives]
Wu-Tu Fan1, Xiang-Long Wu, Ya-Lei Pan
1Key Laboratory of Natural Products Research and Development, China Three Gorges University, Yichang, China.
Abstract:
To explore novel antifatigue agents targeting with AMPA receptor, 10 compounds were synthesized and their structures were confirmed by 1H NMR, ESI-MS and elemental analysis. 1-BCP was treated as the leading compound. The antifatigue activities were evaluated by weight-loaded forced swimming test, and the AMPA receptor binding affinities were tested with radioligand receptor binding assays. The results unveiled that 5b appeared to possess potent antifatigue activities and high affinity with AMPA receptor, which deserved further studies.
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