Related Experiment Video
Updated: Apr 18, 2026
09:44
Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
803
To compound or not to compound: a veterinary transdermal discussion.
Lauren R Eichstadt1, Gigi S Davidson
1University of Findlay, College of Pharmacy, Findlay, OH 45840, USA. eichstadtl@findlay.edu
International Journal of Pharmaceutical Compounding
|January 13, 2015
Summary
Transdermal medication offers a needle-free, stress-free alternative for feline patients. A new checklist helps veterinarians determine if this route is safe and effective for chronic drug administration.
Area of Science:
- Veterinary pharmacotherapy
- Feline medicine
Background:
- Oral and injectable medications present challenges for chronic administration in cats.
- The transdermal route is a potential alternative for feline drug delivery.
- Assessing transdermal therapy requires careful consideration of safety and efficacy.
Purpose of the Study:
- To explore the transdermal route as a solution for feline chronic medication administration.
- To provide a tool for evaluating the suitability of transdermal therapy in cats.
Main Methods:
- Review of existing knowledge on transdermal drug delivery in veterinary medicine.
- Development of a comprehensive checklist for assessing transdermal therapy appropriateness.
- Consideration of patient safety, caregiver safety, and therapeutic effectiveness.
Main Results:
- The transdermal route can be a viable option for certain feline medications.
- A structured checklist aids in the decision-making process for transdermal therapy.
- Key factors include drug properties, patient factors, and administration site.
Conclusions:
- Transdermal medication administration can improve compliance and reduce stress in cats.
- The provided checklist serves as a valuable resource for veterinary pharmacotherapy.
- Careful assessment is crucial to ensure safe and effective transdermal drug use in felines.
Related Concept Videos
01:18Transdermal Drug Delivery Systems
188
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
188
01:13Therapeutic Index
7.8K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
7.8K
01:29Therapeutic Drug Monitoring: Affecting Factors
400
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
400
01:16Therapeutic Drug Monitoring: Overview and Classification
582
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
582
01:29Drug Delivery: Parenteral Route
2.8K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
2.8K
01:16Drug Delivery: Overview
1.2K
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
1.2K