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Effects of bicarbonate-containing versus lactate-containing peritoneal dialysis solutions on superoxide production by
F J Manahan1, B L Ing, J C Chan
1Veterans Administration Hospital, Hines, Illinois 60141.
Artificial Organs
|December 1, 1989
Abstract:
Human neutrophils were isolated from healthy volunteers and exposed to either bicarbonate-containing (pH 7.4) or lactate-containing (pH 5.2) peritoneal dialysis solution in vitro. Superoxide production by neutrophils was measured by a method based on the superoxide dismutase-inhibitable reduction of ferricytochrome c. Bicarbonate-containing peritoneal dialysis solution was found to be superior to the lactate-containing one in facilitating the production of superoxide anion by human neutrophils.