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Updated: Apr 18, 2026

Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry
Published on: March 24, 2012
Site-specific tagging proteins via a rigid, stable and short thiolether tether for paramagnetic spectroscopic
Yin Yang1, Jin-Tao Wang, Ying-Ying Pei
1State-Key Laboratory of Elemento-organic Chemistry, Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin, 300071, China. xunchengsu@nankai.edu.cn.
Abstract:
Increasing the stability of protein bioconjugates and improving the resolution of protein complexes is important for spectroscopic analysis in structural biology. The reaction of phenylsulfonated pyridine derivatives and protein thiols generates a stable, rigid and short thiolether tether, which is valuable in high-resolution spectroscopic measurements.
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