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Updated: Apr 18, 2026

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
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Alternatives to testosterone replacement: testosterone restoration.

Andrew McCullough1

  • 1Department of Urology, Albany Medical College, Albany, New York, USA.

Asian Journal of Andrology
|January 13, 2015
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Summary
This summary is machine-generated.

Late-onset hypogonadism (LOH) in aging men is often secondary. This review explores restoring natural testosterone production, rather than just replacement therapy, for treating LOH.

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Area of Science:

  • Endocrinology
  • Andrology
  • Aging Research

Background:

  • Male aging is frequently associated with secondary hypogonadism.
  • The aging testis can potentially restore testosterone production with pituitary stimulation.

Purpose of the Study:

  • To review literature supporting the restoration of endogenous testosterone production for treating late-onset hypogonadism (LOH).

Main Methods:

  • Literature review of peer-reviewed studies.
  • Focus on treatment strategies for LOH.

Main Results:

  • The European Male Aging Study indicates secondary hypogonadism is common in aging males.
  • Theoretical basis for stimulating endogenous testosterone production exists.

Conclusions:

  • Restoration of endogenous testosterone is a viable therapeutic concept for LOH.
  • Further research into endogenous restoration strategies is warranted.