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Association of matrix metalloproteinase-7 (-181A/G) promoter polymorphism in chronic pancreatitis

K Sri Manjari, A Jyothy, P Shravan Kumar

  • 1Institute of Genetics & Hospital for Genetic Diseases, Osmania University, Hyderabad, India.

The Indian Journal of Medical Research
|January 13, 2015
PubMed
Abstract

Insights

The GG genotype of the Matrix Metalloproteinase-7 (MMP-7) -181A/G gene promoter polymorphism is significantly associated with chronic pancreatitis. This finding suggests a potential genetic link to the irreversible pancreatic disease.

Area of Science:

  • Genetics and Molecular Biology
  • Gastroenterology
  • Biochemistry

Background:

  • Chronic pancreatitis involves irreversible pancreatic tissue destruction.
  • Matrix Metalloproteinase-7 (MMP-7) plays a role in tissue breakdown and angiogenesis.
  • The MMP-7 gene promoter polymorphism -181A/G (rs11568818) was investigated for its association with chronic pancreatitis.

Purpose of the Study:

  • To investigate the association between the MMP-7 -181A/G (rs11568818) gene promoter polymorphism and chronic pancreatitis.
  • To determine if specific genotypes of MMP-7 are risk factors for developing chronic pancreatitis.

Main Methods:

  • A case-control study included 100 chronic pancreatitis patients and 150 healthy controls.
  • Genotyping of the MMP-7 -181A/G polymorphism was performed using PCR-RFLP.
  • Serum MMP-7 levels were measured using ELISA, and associations were analyzed using odds ratios (OR) with 95% confidence intervals (CI).

Main Results:

  • The frequency of the MMP-7 -181GG genotype and the -181G allele was significantly higher in chronic pancreatitis patients compared to healthy subjects (OR = 1.58, p = 0.019).
  • Genotype frequencies in patients were AA 49%, AG 25%, GG 26%, versus controls AA 53%, AG 38%, GG 9%.
  • No significant difference in serum MMP-7 levels was observed between patients and controls.

Conclusions:

  • The MMP-7 -181A/G (rs11568818) GG genotype is significantly associated with chronic pancreatitis.
  • This genetic variation may contribute to the pathogenesis or susceptibility to chronic pancreatitis.
  • Further research is warranted to elucidate the precise role of MMP-7 genetics in pancreatic disease.

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