Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Signaling Feedback Loops01:07

Cell Signaling Feedback Loops

8.1K
Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
8.1K
Overview of Cell Signaling01:23

Overview of Cell Signaling

27.1K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
27.1K
Overview of Cell Signaling01:23

Overview of Cell Signaling

5.1K
5.1K
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

8.8K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
8.8K
Microbial Biosensors01:17

Microbial Biosensors

71
Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
71
Design Example01:23

Design Example

651
The innovation of touch-tone telephony revolutionized the telecommunications industry by replacing the traditional rotary dial with a dual-tone multi-frequency (DTMF) signaling system. This system uses a matrix-style keypad with buttons arranged in four rows and three columns, creating 12 distinct signals each assigned to a pair of frequencies. Each button press results in a simultaneous generation of two sinusoidal tones – one from a low-frequency group (697 to 941 Hz) and one from a...
651

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validity and prognostic value of a novel intraoperative assessment tool for reduction in trimalleolar fractures: the SGSC checklist approach.

Archives of orthopaedic and trauma surgery·2026
Same author

Dendritic Cell-Inspired NCNTs/HEA Architecture for Synergistic Enhancement of Low-Frequency Microwave Absorption and Thermal Conductivity.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

CCT2 Promotes Prostate Cancer Progression Through EIF3F-Dependent Stabilization of FASN.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

c-Fos-driven metabolic switch of α-ketoglutarate orchestrates progression in prostate cancer.

Cell death & disease·2026
Same author

A framework for building a synthetic cell from the SynCell Asia Initiative.

Nature biotechnology·2026
Same author

A Preclinical Study of a PSMA Ligand-Based Dual-Modality Probe for Radical Prostatectomy.

Pharmaceuticals (Basel, Switzerland)·2026
Same journal

Fish immunization by duckweed biomass accumulating recombinant cyprinid herpesvirus 3 antigens induces specific immune response.

New biotechnology·2026
Same journal

Evaluation of Ogataea polymorpha DUR31 TPP riboswitch as a tool to downregulate gene expression in the yeast Komagataella phaffii.

New biotechnology·2026
Same journal

Semi-automated Ribosome Display for High-Throughput DARPin Binder Selection.

New biotechnology·2026
Same journal

Cell Culture Medium Formulation can be a Driver of Lipoprotein Lipase Release and Polysorbate Degradation Risk in CHO Cell-based Manufacturing Processes.

New biotechnology·2026
Same journal

Advancements in cofactor regeneration for efficient UDP-GlcNAc and UDP-GalNAc synthesis.

New biotechnology·2026
Same journal

Metabolic engineering of Saccharomyces cerevisiae sphingolipid pathways for enhanced phytoceramide production.

New biotechnology·2026
See all related articles

Related Experiment Video

Updated: Apr 18, 2026

Rapid Development of Cell State Identification Circuits with Poly-Transfection
09:21

Rapid Development of Cell State Identification Circuits with Poly-Transfection

Published on: February 24, 2023

2.1K

Designer cell signal processing circuits for biotechnology.

Robert W Bradley1, Baojun Wang2

  • 1Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK; Centre for Synthetic and Systems Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, UK.

New Biotechnology
|January 13, 2015
PubMed
Summary
This summary is machine-generated.

Synthetic biology engineers reprogram cellular signal processing for new applications. This involves using biological components for digital and analog computing in designer cells for medicine, environment, and industry.

More Related Videos

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

838
A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

10.9K

Related Experiment Videos

Last Updated: Apr 18, 2026

Rapid Development of Cell State Identification Circuits with Poly-Transfection
09:21

Rapid Development of Cell State Identification Circuits with Poly-Transfection

Published on: February 24, 2023

2.1K
Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

838
A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

10.9K

Area of Science:

  • Synthetic biology
  • Cellular information processing
  • Biotechnology

Background:

  • Microorganisms possess sophisticated information processing capabilities for environmental and metabolic signal response.
  • Synthetic biology aims to engineer cellular signal processing for beneficial applications like disease diagnosis, environmental sensing, and chemical production.

Purpose of the Study:

  • To provide an overview of current components and strategies for designer cell signal processing and decision-making.
  • To discuss the implementation of these systems in prototype applications.
  • To examine emerging challenges in the field of cellular signal processing.

Main Methods:

  • Review of existing biological components for cellular signal manipulation.
  • Analysis of digital and analog computing approaches in synthetic biological signal processing.
  • Case studies of implemented prototype systems in therapeutic, environmental, and industrial biotechnology.

Main Results:

  • Significant progress in expanding the repertoire of biological components for cellular signal processing.
  • Development of both digital and analog computing strategies for increasingly complex cellular behaviors.
  • Demonstrated applications in prototype systems across various biotechnological fields.

Conclusions:

  • Designer cells offer powerful platforms for sophisticated signal processing and decision-making.
  • The field is advancing rapidly, with diverse applications emerging in medicine, environmental monitoring, and industrial bioproduction.
  • Continued research is needed to address challenges and unlock the full potential of engineered cellular systems.