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Related Experiment Video

Updated: Apr 18, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
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Neonates with reduced neonatal lung function have systemic low-grade inflammation.

Bo L K Chawes1, Jakob Stokholm2, Klaus Bønnelykke1

  • 1Copenhagen Prospective Studies on Asthma in Childhood, Health and Medical Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

The Journal of Allergy and Clinical Immunology
|January 13, 2015
PubMed
Summary

Reduced lung function in newborns is linked to higher levels of systemic inflammation markers like high-sensitivity C-reactive protein (hs-CRP). This suggests inflammation may precede asthma symptoms in infants.

Keywords:
Asthmachildrenhigh-sensitivity C-reactive proteinproinflammatory cytokinesspirometry

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Area of Science:

  • Pediatric Pulmonology
  • Neonatal Health
  • Immunology

Background:

  • Asthma and impaired lung function in children and adults are associated with low-grade systemic inflammation.
  • It remains unclear if this inflammation begins before symptom onset.
  • This study investigates inflammation in asymptomatic neonates with reduced lung function.

Purpose of the Study:

  • To explore the association between neonatal lung function and systemic inflammation biomarkers.
  • To determine if early lung function predicts later inflammatory markers.

Main Methods:

  • Neonatal lung function was tested in 300 infants at 4 weeks of age.
  • Plasma inflammatory biomarkers (hs-CRP, IL-1β, IL-6, TNF-α, CXCL8) were measured at 6 months.
  • Statistical analyses included conventional methods and principal component analysis.

Main Results:

  • Neonatal forced expiratory volume at 0.5 seconds showed an inverse association with hs-CRP and IL-6 levels at 6 months.
  • Principal component analysis confirmed an inflammatory profile in infants with reduced neonatal lung function.
  • These associations remained significant after adjusting for various confounding factors.

Conclusions:

  • Diminished neonatal lung function is associated with increased systemic inflammatory markers.
  • High-sensitivity C-reactive protein (hs-CRP) is one such marker linked to reduced early lung function.