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Published on: February 8, 2020
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Clear cell sarcoma of the kidney: a case report
Dipanwita Nag, Ayandip Nandi1, Palash Kumar Mandal
1Department of Pathology, Medical College, Kolkata, India.
Journal of Cancer Research and Therapeutics
|January 13, 2015
Summary
Clear cell sarcoma of the kidney is a rare and aggressive childhood cancer. This case highlights a stage-II diagnosis in an infant, emphasizing the need for vigilance against metastasis.
Area of Science:
- Pediatric Oncology
- Nephropathology
Background:
- Clear cell sarcoma of the kidney (CCSK) is a rare and aggressive pediatric malignancy.
- It is characterized by a high propensity for recurrence and bone metastasis.
Observation:
- An 8-month-old infant presented with a large abdominal mass, initially suspected as Wilms tumor.
- A left nephrectomy was performed, revealing a 10 cm encapsulated renal mass.
Findings:
- Histological examination confirmed clear cell sarcoma of the kidney.
- Tumor emboli were identified in the renal vein, and the tumor was staged as II (NWTS-5 protocol).
- Immunohistochemistry revealed vimentin-positive and cytokeratin-negative tumor cells.
Implications:
- This case underscores the importance of accurate diagnosis of CCSK in infants.
- Early detection and appropriate staging are crucial for managing this aggressive neoplasm.
- Ongoing chemotherapy aims to prevent potential bony metastasis, a known complication of CCSK.
