Anisotropic swelling of thin gel sheets
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Updated: Apr 18, 2026

Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses
Published on: March 25, 2015
Paola Nardinocchi1, Matteo Pezzulla, Luciano Teresi
1Sapienza Università di Roma, via Eudossiana 18, Roma, Italy. paola.nardinocchi@uniroma1.it.
Abstract:
We describe the anisotropic swelling within the Flory-Rehner thermodynamic model through an extension of the elastic component of the free-energy, which takes into account the oriented hampering of the swelling-induced deformations due to the presence of stiffer fibers. We also characterize the homogeneous free-swelling solutions of the corresponding anisotropic stress-diffusion problem, and discuss an asymptotic approximation of the key equations, which allows us to explicitly derive the anisotropic solution of the problem. We propose a proof-of-concept of our model, realizing thin bilayered gel sheets with layers having different anisotropic structures. In particular, for seedpod-like sheets, we observe and quantitatively measure the helicoid versus ribbon transition determined by the aspect ratio of the composite sheet.

