Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Response Surface Methodology01:16

Response Surface Methodology

891
Response Surface Methodology (RSM) is a collection of statistical and mathematical techniques used to develop, improve, and optimize processes. It is particularly valuable when many input variables or factors potentially influence a response variable.
The process of RSM involves several key steps:
891
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

2.1K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
2.1K
Methods of Medium Optimization01:28

Methods of Medium Optimization

63
Optimizing growth media enhances microbial proliferation and maximizes product yield. Statistical experimental design methodologies provide structured and reproducible approaches, offering progressively higher levels of robustness and efficiency.The One-Factor-at-a-Time (OFAT) MethodThe One-Factor-at-a-Time (OFAT) method involves adjusting a single variable while keeping all others constant. However, it cannot detect interactions between variables, often leading to suboptimal outcomes when...
63
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

793
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
793
Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

Modified-Release Drug Delivery Systems: Drug Release Characteristics

231
Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
231
In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

376
Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
376

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of Known Flavonoids of <i>Ficus carica</i> L. as Aldose Reductase Inhibitors in Sciatic Nerve of Diabetic Neuropathy-induced Rats through Bioinformatics and Proteomics Analysis.

CNS & neurological disorders drug targets·2025
Same author

Advances in dorzolamide hydrochloride delivery: harnessing nanotechnology for enhanced ocular drug delivery in glaucoma management.

Discover nano·2024
Same author

Development of an Analytical Quality by Design RP-HPLC Method and Its Validation for Estimation of Gefitinib From Bulk, Tablet Dosage Form, and Complex Nanoformulation.

Journal of AOAC International·2024
Same author

Sulfobutylether-β-cyclodextrin: A functional biopolymer for drug delivery applications.

Carbohydrate polymers·2022
Same author

Statistical optimization of voriconazole nanoparticles loaded carboxymethyl chitosan-poloxamer based in situ gel for ocular delivery: In vitro, ex vivo, and toxicity assessment.

Drug delivery and translational research·2022
Same author

Effect of process parameters on the recovery of lactose in an antisolvent acetone/acetone-ethanol mixture: A comparative study based on sonication medium.

Ultrasonics sonochemistry·2020

Related Experiment Video

Updated: Apr 18, 2026

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development
06:00

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development

Published on: March 17, 2023

978

Optimization of sustained release aceclofenac microspheres using response surface methodology.

Rameshwar K Deshmukh1, Jitendra B Naik1

  • 1Department of Pharmaceutical Technology, University Institute of Chemical Technology, North Maharashtra University, Jalgaon, 425 001 Maharashtra, India.

Materials Science & Engineering. C, Materials for Biological Applications
|January 13, 2015
PubMed
Summary

Aceclofenac polymeric microspheres were developed using response surface methodology (RSM) for enhanced drug delivery. Optimized formulations achieved high encapsulation efficiency and sustained release, suggesting improved therapeutic outcomes with fewer side effects.

Keywords:
Aceclofenac microspheresBiocompatible polymersIV-Optimal designMicroencapsulationResponse surface methodology

More Related Videos

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.7K
A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM
13:54

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM

Published on: August 18, 2023

6.3K

Related Experiment Videos

Last Updated: Apr 18, 2026

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development
06:00

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development

Published on: March 17, 2023

978
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.7K
A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM
13:54

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM

Published on: August 18, 2023

6.3K

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) used for pain and inflammation.
  • Conventional drug delivery systems can lead to fluctuating plasma concentrations and gastrointestinal side effects.
  • Polymeric microspheres offer a potential strategy for sustained drug release and improved therapeutic efficacy.

Purpose of the Study:

  • To develop and optimize polymeric microspheres containing aceclofenac using response surface methodology (RSM).
  • To enhance the encapsulation efficiency (E.E.) and achieve sustained in vitro drug release.
  • To evaluate the physicochemical properties and drug-polymer interactions of the optimized microspheres.

Main Methods:

  • Single emulsion (oil-in-water) solvent evaporation method was employed.
  • Response surface methodology (RSM) with a statistical experimental design was used to optimize Eudragit® RS100 and polyvinyl alcohol (PVA) concentrations.
  • Microsphere characterization included size, morphology, E.E., in vitro drug release, FTIR, DSC, and XRPD.

Main Results:

  • RSM identified Eudragit® RS100 and PVA amounts as significant factors influencing E.E.
  • Optimized microspheres exhibited high E.E. (up to 85.34%) and sustained drug release over 12 hours (40-60%).
  • Physicochemical analyses confirmed drug dispersion within the microspheres and absence of drug-polymer interactions.

Conclusions:

  • The developed polymeric microspheres are a promising system for sustained delivery of aceclofenac.
  • Optimized formulations demonstrate potential for prolonged drug action and reduced gastrointestinal side effects.
  • RSM proved effective in optimizing microsphere formulation for enhanced drug delivery characteristics.