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Biomarkers in the primary progressive aphasias
1Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Biomarkers aid in diagnosing the cause of primary progressive aphasia (PPA), a neurodegenerative language disorder. Combining clinical exams with biomarker assessments promises accurate in-life diagnosis for PPA patients.
Area of Science:
- Neurology
- Neurodegeneration
- Linguistics
Background:
- Primary progressive aphasia (PPA) is a progressive language disorder.
- PPA is recognized as a key manifestation within a spectrum of neurodegenerative diseases.
Purpose of the Study:
- To review biomarkers for identifying the histopathologic basis of PPA.
- Crucial for developing etiologically specific treatments for neurodegenerative conditions.
Main Methods:
- Review of genetic studies.
- Review of neuroimaging studies.
- Review of biofluid studies.
Main Results:
- Clinical syndromes offer probabilistic links to PPA pathology but have exceptions.
- Biomarker research is increasingly vital for clinical diagnosis.
- Genetic, neuroimaging, and biofluid data aid in determining PPA pathology.
Conclusions:
- Biomarker assessments supplement clinical examination for PPA diagnosis.
- Accurate in-life diagnosis of PPA pathology is achievable.
- Biomarkers will facilitate clinical trials for PPA spectrum disorders.
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