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The roles of CD147 and/or cyclophilin A in kidney diseases
Xin Qu1, Chunting Wang2, Jicheng Zhang2
1Department of Critical Care Medicine, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan 250021, China ; Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantan Xili, Beijing 100050, China.
Abstract:
CD147 is a widely expressed integral plasma membrane glycoprotein and has been involved in a variety of physiological and pathological activities in combination with different partners, including cyclophilins, caveolin-1, monocarboxylate transporters, and integrins. Recent data demonstrate that both CyPA and CD147 significantly contribute to renal inflammation, acute kidney injury, renal fibrosis, and renal cell carcinoma. Here we review the current understanding of cyclophilin A and CD147 expression and functions in kidney diseases and potential implications for treatment of kidney diseases.
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