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Development of Injectable Citrate-Based Bioadhesive Bone Implants.

Denghui Xie1, Jinshan Guo2, Mohammadreza Mehdizadeh2

  • 1Department of Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University; Academy of Orthopedics, Guangdong Province; Biology Department, Southern Medical University, Guangzhou, 510515, China ; Department of Biomedical Engineering, Materials Research Institutes, The Huck Institutes of The Life Sciences, The Pennsylvania State University, University Park 16802, USA.

Journal of Materials Chemistry. B
|January 13, 2015
PubMed
Summary
This summary is machine-generated.

A new injectable bone substitute, iCMBA/HA, utilizes citrate to enhance bone healing in comminuted bone fractures (CBF). This material shows improved adhesion, osteoinductivity, and promotes significant bone regeneration in animal models.

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Regenerative Medicine

Background:

  • Injectable bone implants are crucial for bone tissue repair, particularly for comminuted bone fractures (CBF).
  • Existing implants often suffer from inadequate tissue adhesion and osteoinduction, limiting their efficacy in treating complex fractures.
  • Citrate has emerged as a promising agent for enhancing bone formation by improving bioceramic integration and osteoinductivity.

Purpose of the Study:

  • To develop and evaluate a novel injectable citrate-based mussel-inspired bioadhesive hydroxyapatite (iCMBA/HA) bone substitute for treating comminuted bone fractures (CBF).
  • To investigate the effects of citrate on human mesenchymal stem cells (hMSCs) mineralization and bone formation in vivo.

Main Methods:

  • Synthesis and characterization of the injectable citrate-based mussel-inspired bioadhesive hydroxyapatite (iCMBA/HA).
  • Assessment of iCMBA/HA properties including setting time, swelling ratio, mechanical strength, degradation, biocompatibility, and osteoinductivity.
  • In vitro studies on citrate's effect on osteoblastic committed human mesenchymal stem cells (hMSCs) mineralization.
  • In vivo evaluation of iCMBA/HA in a rabbit comminuted radial fracture model.

Main Results:

  • The developed iCMBA/HA sets rapidly (2-4 minutes) with low swelling, good mechanical strength (3.2±0.27 MPa), and complete degradation within 30 days.
  • Citrate supplementation and release from iCMBA/HA significantly promoted hMSCs mineralization.
  • In vivo studies demonstrated significantly enhanced bone formation and three-point bending strength in rabbit CBF models treated with iCMBA/HA.
  • iCMBA/HA implantation led to observed neovascularization, bone ingrowth, and highly organized bone regeneration.

Conclusions:

  • The novel iCMBA/HA demonstrates excellent properties as an injectable bone substitute for comminuted bone fracture treatment.
  • Citrate plays a key role in enhancing osteogenesis and bone regeneration through improved mineralization and integration.
  • iCMBA/HA shows significant potential for clinical application in treating comminuted bone fractures.