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Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in

Tomoyasu Kadoguchi1, Shintaro Kinugawa, Shingo Takada

  • 1Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita-ku, Hokkaido, Sapporo, Japan.

Experimental Physiology
|January 13, 2015
PubMed
Summary
This summary is machine-generated.

Angiotensin II directly causes skeletal muscle abnormalities, including mitochondrial dysfunction and fiber type changes, leading to reduced exercise capacity. These findings highlight its role in disease-related muscle weakness.

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Area of Science:

  • Physiology
  • Molecular Biology
  • Exercise Science

Background:

  • Skeletal muscle abnormalities reduce exercise capacity in aging and diseases like heart failure.
  • The renin-angiotensin system, specifically angiotensin II (Ang II), is implicated in these conditions.

Purpose of the Study:

  • To investigate if Ang II directly induces skeletal muscle abnormalities.
  • To determine the time course of these Ang II-induced changes.

Main Methods:

  • Male C57BL/6J mice received Ang II or vehicle via osmotic minipumps for 1 or 4 weeks.
  • Evaluated body and muscle weights, muscle fiber cross-sectional area, and markers of atrophy and apoptosis.
  • Assessed mitochondrial enzyme activities, oxidative stress, fiber type distribution, and exercise performance via treadmill tests.

Main Results:

  • Ang II administration decreased body and muscle weights, muscle fiber size, and mitochondrial enzyme activities.
  • Increased markers of apoptosis and oxidative stress were observed.
  • Reduced exercise capacity, decreased oxidative fibers (Type I), and increased glycolytic fibers (Type IIb) were noted.

Conclusions:

  • Angiotensin II directly induces skeletal muscle abnormalities, including mitochondrial dysfunction, fiber type alterations, and atrophy.
  • These changes contribute to reduced exercise capacity.
  • Ang II plays a significant role in skeletal muscle dysfunction associated with various diseases.