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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
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Anti-HLA antibody testing in hematology patients
Jeremy Ryan A Peña1, Susan L Saidman
1Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Department of Pathology, Harvard Medical School, Boston, Massachusetts.
American Journal of Hematology
|January 13, 2015
Summary
Anti-human leukocyte antigen (HLA) antibody testing is crucial for hematology patients, guiding donor selection for stem cell and platelet transplants. This review focuses on solid-phase multiplex assays and their laboratory and clinical considerations.
Area of Science:
- Immunology
- Hematology
- Transplantation
Background:
- Anti-human leukocyte antigen (HLA) antibodies pose significant challenges in hematology patient care.
- Accurate HLA antibody detection is vital for successful stem cell and platelet transplantation.
Purpose of the Study:
- To review current human leukocyte antigen (HLA) antibody testing methods.
- To emphasize laboratory and clinical issues related to solid-phase multiplex assays for HLA antibodies.
Main Methods:
- Review of existing literature on human leukocyte antigen (HLA) antibody testing.
- Focus on solid-phase multiplex assay methodologies.
Main Results:
- Human leukocyte antigen (HLA) antibody testing is essential for donor selection in stem cell and platelet recipients.
- Solid-phase multiplex assays are increasingly used but present specific laboratory and clinical challenges.
Conclusions:
- Effective management of hematology patients relies on precise human leukocyte antigen (HLA) antibody testing.
- Understanding the nuances of solid-phase multiplex assays is key for optimizing patient care and transplant outcomes.
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