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Related Concept Videos

Preparation and Reactions of Thiols02:33

Preparation and Reactions of Thiols

8.1K
Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.
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Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

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Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
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Related Experiment Video

Updated: Apr 18, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
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Functional graphene by thiol-ene click chemistry.

Nguyen Dang Luong1, Le Hoang Sinh, Leena-Sisko Johansson

  • 1Department of Biotechnology and Chemical Technology, Aalto University School of Chemical Technology, Espoo, P.O. Box 16100, I00076 Aalto (Finland).

Chemistry (Weinheim an Der Bergstrasse, Germany)
|January 13, 2015
PubMed
Summary

A novel thiol-ene click reaction modifies graphene oxide (GO) into nitrogen-sulfur doped GO (NS-GO). This functionalized graphene exhibits excellent dispersion and serves as a matrix for platinum nanoparticles, enabling new nanocomposite materials.

Keywords:
chemical modificationgraphenenanomaterialsplatinumthiol-ene reactions

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemical Engineering

Background:

  • Graphene oxide (GO) is a promising material but requires effective chemical modification for advanced applications.
  • Developing scalable and efficient methods for functionalizing GO is crucial for creating novel nanomaterials.

Purpose of the Study:

  • To chemically modify graphene oxide (GO) using a one-step thiol-ene click reaction.
  • To synthesize nitrogen- and sulfur-containing functionalized graphene oxide (NS-GO).
  • To evaluate the properties and potential applications of the modified graphene oxide.

Main Methods:

  • Employed a thiol-ene click reaction with cysteamine hydrochloride and 2,2-azobis(2-methylpropionitrile) (AIBN) as a thermal catalyst.
  • Incorporated thiol-containing compounds onto the GO surface via reaction with C=C bonds.
  • Deprotected the amine group using sodium hydroxide to yield NS-GO.

Main Results:

  • Successfully synthesized nitrogen- and sulfur-doped graphene oxide (NS-GO) through a one-step process.
  • NS-GO demonstrated good dispersibility in water, ethanol, and ethylene glycol.
  • NS-GO served as an excellent host matrix for platinum nanoparticles, forming functional nanocomposites.

Conclusions:

  • The developed thiol-ene click reaction provides an efficient method for GO modification.
  • NS-GO exhibits enhanced dispersion properties and suitability for creating functional nanocomposites.
  • This approach offers a new pathway for graphene functionalization and the development of advanced graphene-based materials.