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E-norms: a method to extrapolate reference values from a laboratory population
Joe F Jabre1, Matthew C Pitt, Jacquie Deeb
1*Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, U.S.A.; †Department of Clinical Neurophysiology, Great Ormond Street Hospital for children NHS Foundation Trust, London, United Kingdom; ‡Department of Neurophysiology, Queen's Hospital, Barking, Havering and Redbridge University Hospitals NHS Trust, London, United Kingdom; and §Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts, U.S.A.
Extrapolated norms (e-norms) successfully derive reference values for Stimulated Single Fiber EMG jitter in pediatric populations. This method provides reliable data when direct collection is challenging, aiding in diagnosing neuromuscular disorders.
Area of Science:
- Neurology
- Clinical Electrophysiology
Background:
- Collecting reference values for pediatric subpopulations in epidemiologic studies is challenging.
- Single Fiber EMG (Electromyography) is the gold standard for diagnosing neuromuscular transmission disorders.
Purpose of the Study:
- To evaluate the extrapolated norms (e-norms) method for deriving Stimulated Single Fiber EMG jitter reference values.
- To establish reference values in pediatric and adult cohorts using e-norms.
Main Methods:
- Utilized data from the plateau region of an inverted S-curve derived from sorted jitter data.
- Calculated descriptive statistics for pediatric and adult e-norms jitter.
Main Results:
- The e-norms derived jitter was 22 ± 2.83 μs for the pediatric cohort and 21 ± 2.79 μs for the adult cohort.
- Adult e-norms values closely matched previously published reference ranges for healthy adults.
Conclusions:
- The e-norms method is effective for obtaining reference ranges in difficult-to-study subpopulations, particularly pediatrics.
- This approach aids in establishing crucial reference values for pediatric neuromuscular assessments.
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