Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tumor characterization using unconventional MR modalities.

R H Griffey1

  • 1Center for Noninvasive Diagnosis, University of New Mexico School of Medicine, Albuquerque 87131.

Investigative Radiology
|December 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mass spectrometry as a drug discovery platform against RNA targets.

Current opinion in drug discovery & development·2009
Same author

Raman and infrared studies of nucleosides at high pressures: II. Cytidine.

Journal of biomolecular structure & dynamics·2002
Same author

Analysis of noncovalent complexes of DNA and RNA by mass spectrometry.

Chemical reviews·2001
Same author

An efficient synthesis of mimetics of neamine for RNA recognition.

Organic letters·2001
Same author

Spontaneous base flipping in DNA and its possible role in methyltransferase binding.

Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics·2000
Same author

Base opening in RNA and DNA duplexes: implication for RNA stability.

Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics·2000

This review covers advanced magnetic resonance (MR) techniques for tumor analysis, focusing on proton MR spectroscopy (MRS), diffusion and perfusion imaging, and sodium ion imaging. These methods offer unique insights into tumor structure and metabolism, with many nearing clinical application.

Area of Science:

  • Medical Imaging
  • Biophysics
  • Oncology

Background:

  • Accurate tumor characterization is crucial for effective cancer treatment.
  • Traditional imaging methods have limitations in assessing tumor metabolism and microenvironment.
  • Novel magnetic resonance (MR) techniques offer advanced capabilities for in-vivo tumor evaluation.

Purpose of the Study:

  • To review promising new magnetic resonance (MR) modalities for characterizing tumor structure and metabolism.
  • To discuss the technical challenges and unique information provided by these advanced MR techniques.
  • To highlight the clinical relevance and imminent applications of these emerging MR methods.

Main Methods:

  • Review of recent advancements in localized proton magnetic resonance spectroscopy (MRS).

Related Experiment Videos

  • Analysis of MR imaging techniques for diffusion and perfusion.
  • Discussion of methods for imaging bound pools of sodium ions.

    • Main Results:

    • Localized proton MRS provides insights into tumor metabolism.
    • Diffusion and perfusion imaging reveal information about tumor microenvironment and vascularity.
    • Sodium ion imaging offers a novel approach to assess tumor cellularity and structure.

    Conclusions:

    • Advanced MR techniques like localized proton MRS, diffusion/perfusion imaging, and sodium ion imaging show significant promise for tumor characterization.
    • These methods provide unique, complementary information to conventional diagnostics.
    • Clinical applications of these MR modalities are imminent, paving the way for improved cancer diagnosis and management.