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Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
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[Treatment options for serious infections caused by vancomycin-resistant enterococci]
Nico T Mutters1, Guido Werner2, Evelina Tacconelli3
1Deutsches Zentrum für Infektionsforschung (DZIF) Heidelberg, Universitätsklinikum Heidelberg.
Deutsche Medizinische Wochenschrift (1946)
|January 13, 2015
Summary
Vancomycin-resistant enterococci (VRE) infections pose a treatment challenge due to limited options. This review evaluates linezolid, tigecycline, and daptomycin for VRE therapy, highlighting current data limitations.
Area of Science:
- Infectious Diseases
- Microbiology
- Pharmacology
Background:
- Complicated vancomycin-resistant enterococci (VRE) infections present significant therapeutic challenges.
- Limited effective antibiotic options and emerging resistance complicate VRE treatment.
- Linezolid is commonly used, but alternatives like tigecycline and daptomycin have scarce or restricted clinical data for severe VRE infections.
Purpose of the Study:
- To critically evaluate the clinical significance of linezolid, tigecycline, and daptomycin for treating vancomycin-resistant enterococci (VRE) infections.
- To review existing clinical data on these antibiotics in the context of VRE therapy.
- To identify therapeutic challenges and data gaps in managing complicated VRE infections.
Main Methods:
- Literature review of existing clinical data.
- Critical evaluation of antibiotic efficacy and resistance patterns.
- Analysis of antibiotic use for vancomycin-resistant enterococci (VRE) infections.
Main Results:
- Linezolid is frequently employed for VRE infections.
- Tigecycline serves as an alternative, but data for severe conditions like sepsis and endocarditis are limited.
- Daptomycin is a potential option, though not yet approved for enterococcal infections in Germany.
Conclusions:
- Effective treatment of vancomycin-resistant enterococci (VRE) infections remains a challenge.
- Further clinical data are needed, especially for tigecycline and daptomycin in severe VRE infections.
- The clinical utility of available antibiotics for VRE requires ongoing assessment based on emerging evidence.
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