Emergence delirium, pain or both? A challenge for clinicians
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Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex
Published on: July 4, 2018
Marta Somaini1, Emre Sahillioğlu, Chiara Marzorati
1Department of Anaesthesia and Intensive Care, Niguarda Ca' Granda Hospital, Milan-Bicocca University, Milan, Italy.
Insights
Differentiating emergence delirium (ED) from pain in children post-anesthesia is challenging. Specific behaviors like lack of eye contact indicate ED, but inconsolability and restlessness are unreliable for distinguishing pain or ED.
Area of Science:
- Pediatric Anesthesiology
- Postoperative Care
- Behavioral Science
Background:
- Children frequently exhibit negative behaviors post-anesthesia, including emergence delirium (ED) and pain.
- Distinguishing between ED and pain is difficult for caregivers in the early postoperative period.
Purpose of the Study:
- To evaluate the ability of validated pediatric observational scales to differentiate ED from pain in young children.
- To assess the utility of the Paediatric Anaesthesia Emergence Delirium Scale (PAED) and the Face, Legs, Activity, Cry, Consolability (FLACC) scale.
Main Methods:
- Prospective observational study of 150 children undergoing elective adenoidectomy/tonsillectomy.
- Simultaneous behavioral evaluation using PAED and FLACC scales by trained observers at extubation and 5, 10, 15 minutes post-procedure.
Main Results:
- 21% of children experienced ED, 5% pain, and 65% had both.
- 'No eye contact,' 'No purposeful action,' and 'No awareness of surroundings' (ED1) showed high sensitivity (0.96) and specificity (0.80) for identifying ED.
- 'Inconsolability' and 'Restlessness' (ED2) had lower sensitivity (0.69) but higher specificity (0.88) for pain, though overall reliability was limited.
Conclusions:
- Differentiating ED and pain using FLACC and PAED scores in the immediate postoperative phase is challenging.
- Specific ED behaviors ('No eye contact,' etc.) correlate with ED, but 'Inconsolability' and 'Restlessness' are not reliable indicators for pain or ED within 15 minutes of awakening.
Background:
Children commonly display early postoperative negative behavior (e-PONB) after general anesthesia, which includes emergence delirium (ED), discomfort, temperament, and pain. However, it is often difficult for the caregiver to discriminate between various aspects of e-PONB.
Objective:
This prospective observational study evaluates the possibility to distinguish between ED and pain in young children using validated pediatric observational scales in the early postoperative phase.
Methods:
Following institutional approval and written consent, children undergoing elective adenoidectomy and/or tonsillectomy were enrolled. Following standardized anesthesia, two trained observers simultaneously evaluated children's behavior with the Paediatric Anaesthesia Emergence Delirium Scale (PAED) and with the Face, Legs, Activity, Cry, Consolability scale (FLACC) at extubation, and at 5, 10, and 15 min.
Results:
Of 150 children that completed the study, 32 (21%) had ED, 7 (5%) had pain, and 98 (65%) had simultaneously both ED and pain. The association of 'No eye contact', 'No purposeful action' and 'No awareness of surroundings' (ED1) had a sensitivity of 0.96 and a specificity of 0.80 (PPV 0.97, NPV 0.78) to identify ED. 'Inconsolability' and 'Restlessness' (ED2) had a sensitivity of 0.69 and a specificity of 0.88 (PPV 0.83 and NPV 0.78) to identify pain.
Conclusion:
It is difficult to differentiate between ED and pain using FLACC and PAED scores. 'No eye contact', 'No purposeful action', and 'No awareness of surroundings' significantly correlated with ED. 'Inconsolability' and 'Restlessness' are not reliable enough to identify pain or ED in the first 15 min after awakening.
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